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[Tropical endomyocardial fibrosis: Perspectives]
M Lachaud1, C Lachaud2, D Sidi3
1Thorax Institute, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France; Service de Cardiologie pédiatrique, Centre Hospitalier Universitaire de Sainte Justine, Montréal, Québec, Canada; Instituto do Coraçao, 1111, avenue Kenneth-Kaunda, Maputo, Mozambique.
Annales De Cardiologie Et D'Angeiologie
|April 1, 2018
Summary
Tropical endomyocardial fibrosis (FET) is a major cause of heart failure and restrictive cardiomyopathy globally. Understanding its unclear origins and improving diagnostics are key to better patient outcomes.
Area of Science:
- Cardiology
- Tropical Medicine
- Pathology
Background:
- Tropical endomyocardial fibrosis (FET) is a primary cause of heart failure and the most prevalent restrictive cardiomyopathy worldwide.
- The condition is characterized by extensive ventricular endocardial fibrosis, leading to architectural distortion, impaired cardiac filling, and valvular insufficiency.
- FET is geographically restricted, with an obscure etiology and a poor prognosis.
Purpose of the Study:
- To review the current understanding of tropical endomyocardial fibrosis (FET).
- To highlight recent changes in disease burden and advancements in diagnostic tools.
- To explore alternative approaches for disease comprehension and therapeutic strategies.
Main Methods:
- Literature review of studies on tropical endomyocardial fibrosis.
- Analysis of recent epidemiological data from endemic areas.
- Evaluation of emerging diagnostic techniques.
Main Results:
- Recent reports indicate a changing disease burden in some endemic regions.
- Refined diagnostic tools are becoming available for FET.
- The etiology of FET remains largely unknown.
Conclusions:
- Despite challenges, advancements in diagnostics and evolving epidemiological data offer new avenues for FET research.
- Further investigation into the etiology and improved diagnostic capabilities are crucial for developing effective treatments.
- A better understanding of FET is essential for improving the grim prognosis associated with this condition.
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