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Updated: Feb 12, 2026

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice
Published on: August 23, 2007
Role of lymph node dissection in renal cell cancer
Nirmal Thampi John1, Kyle A Blum1, A Ari Hakimi1
1Department of Surgery, Urology service, Memorial Sloan Kettering cancer center, NYC, NY.
Abstract:
Lymph node metastasis in renal cell cancer (RCC) portends an extremely poor prognosis. Despite proven staging benefit, the therapeutic value of lymph node dissection in RCC remains questionable. The only prospective randomized trial examining its role failed to show any benefit. However, subsequent retrospective publications have attempted to identify high-risk cohorts and clinical scenarios where removal of nodes may improve survival. The aim of this article is to provide a comprehensive review looking at the role of lymph node dissection in RCC if any, the ideal extent of dissection, and also tools a clinician could employ to identify those who would most likely benefit from this exercise.
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