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Related Concept Videos

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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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Related Experiment Video

Updated: Feb 12, 2026

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy
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Macular corneal dystrophy: A review.

Shruti Aggarwal1, Travis Peck1, Jeffrey Golen1

  • 1Department of Ophthalmology, University of Virginia, Charlottesville, Virginia, USA.

Survey of Ophthalmology
|April 1, 2018
PubMed
Summary
This summary is machine-generated.

Macular corneal dystrophy causes progressive vision loss due to abnormal proteoglycan synthesis. Gene and enzyme therapies are being explored for permanent treatment of this genetic corneal condition.

Keywords:
corneal imaging in macular corneal dystrophygenetic basis of corneal macular dystrophymacular corneal dystrophymacular corneal dystrophy treatmentstromal corneal dystrophies

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Area of Science:

  • Ophthalmology
  • Genetics
  • Biochemistry

Background:

  • Macular corneal dystrophy is an inherited condition causing progressive vision loss.
  • It results from abnormal proteoglycan synthesis due to mutations in carbohydrate sulfotransferase genes.
  • This leads to impaired corneal transparency and reduced vision.

Purpose of the Study:

  • To review the pathophysiology, diagnosis, and treatment of macular corneal dystrophy.
  • To highlight advancements in imaging and surgical interventions.
  • To discuss emerging therapeutic strategies like gene and enzyme replacement therapies.

Main Methods:

  • Review of existing literature on macular corneal dystrophy.
  • Analysis of diagnostic imaging techniques like in vivo confocal microscopy and anterior segment ocular coherence tomography.
  • Evaluation of current and novel treatment modalities.

Main Results:

  • Imaging techniques improve understanding of corneal ultrastructural changes without biopsies.
  • Traditional penetrating keratoplasty is effective but newer surgeries like DALK and PRK are also used.
  • Disease recurrence is a significant challenge impacting visual outcomes.

Conclusions:

  • Macular corneal dystrophy is a complex genetic disorder requiring advanced diagnostic and therapeutic approaches.
  • Gene-targeting and enzyme replacement therapies show promise for permanent treatment.
  • Further research is needed to understand gene-deposit relationships and develop effective pharmaceutical agents.