Related Experiment Video

Updated: Feb 12, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

13.9K

Animal Models of Uveal Melanoma for Localized Interventions

George Bontzos1, Efstathios T Detorakis1

  • 1Department of Ophthalmology, University Hospital of Heraklion, Crete, Greece.

Critical Reviews in Oncogenesis
|April 2, 2018
PubMed

Insights

Uveal melanoma, a common eye cancer, requires effective treatments. This review analyzes animal models for studying uveal melanoma and developing localized interventions, aiding researchers in selecting optimal models for their targets.

Area of Science:

  • Ophthalmology
  • Oncology
  • Translational Medicine

Background:

  • Uveal melanoma is the most frequent primary intraocular malignancy in adults.
  • Metastatic disease poses a significant risk of mortality.
  • Current treatment focuses on local tumor control and metastasis management.

Purpose of the Study:

  • To systematically review and analyze animal models for uveal melanoma research.
  • To evaluate the suitability of different models for studying localized interventions.
  • To guide researchers in selecting appropriate animal models based on specific research objectives.

Main Methods:

  • Systematic review of existing literature on uveal melanoma animal models.
  • Analysis of spontaneous, transgenetic, and induced models.
  • Evaluation of model advantages and disadvantages for localized interventions.

Main Results:

  • Multiple animal models exist for uveal melanoma research, each with unique strengths and weaknesses.
  • Models vary in their ability to recapitulate human disease aspects and facilitate therapeutic evaluation.
  • No single model is universally optimal; selection depends on the research question.

Conclusions:

  • Animal models are crucial for understanding uveal melanoma pathogenesis and testing therapies.
  • Careful consideration of model characteristics is necessary for successful research outcomes.
  • This review provides a framework for informed animal model selection in uveal melanoma research.

More Related Videos

Generation of a Liver Orthotopic Human Uveal Melanoma Xenograft Platform in Immunodeficient Mice04:02

Generation of a Liver Orthotopic Human Uveal Melanoma Xenograft Platform in Immunodeficient Mice

Published on: November 6, 2019

9.3K
Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD06:09

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Published on: February 2, 2017

7.2K

Related Concept Videos

Nursing Interventions I: Taxonomy of Nursing Interventions01:03

Nursing Interventions I: Taxonomy of Nursing Interventions

Nursing interventions are chosen as part of the planning process to achieve patient outcomes. Once nursing diagnoses are determined, the goals and outcomes are specified, then the nursing interventions are selected and individualized according to the patient's situation.
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
3.9K
Nursing Interventions II: Selecting and Classifying the Nursing Interventions01:29

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
3.4K
Community Based Intervention01:30

Community Based Intervention

Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
487
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
515
Tonicity in Animals00:59

Tonicity in Animals

The tonicity of a solution determines if a cell gains or loses water in that solution. The tonicity depends on the permeability of the cell membrane for different solutes and the concentration of nonpenetrating solutes in the solution within and outside of the cell. If a semipermeable membrane hinders the passage of some solutes but allows water to follow its concentration gradient, water moves from the side with low osmolarity (i.e., less solute) to the side with higher osmolarity (i.e.,...
126.0K
Tonicity in Animals01:16

Tonicity in Animals

Tonicity describes the amount of solute in a solution. The measure of the tonicity of a solution, or the total amount of solutes dissolved in a specific amount of solution, is called its osmolarity. Three terms—hypotonic, isotonic, and hypertonic—are used to relate the osmolarity of a cell to the osmolarity of the extracellular fluid that contains the cells. In a hypotonic solution, such as tap water, the extracellular fluid has a lower concentration of solutes than the fluid inside...
5.4K