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Targeting the Overexpressed YY1 in Cancer Inhibits EMT and Metastasis

Anne Arah Cho1, Benjamin Bonavida2

  • 1Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California.

Critical Reviews in Oncogenesis
|April 2, 2018
PubMed

Insights

Targeting Yin Yang 1 (YY1), a protein linked to cancer spread and drug resistance, shows promise for new anti-cancer therapies. Inhibiting YY1 may stop cancer growth, metastasis, and overcome treatment resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cancer metastasis remains a significant challenge, with limited therapeutic options for metastatic disease.
  • The epithelial-mesenchymal transition (EMT) is crucial for metastasis, conferring resistance to conventional therapies.
  • Yin Yang 1 (YY1) is implicated in EMT, drug resistance, cell survival, and proliferation, and its overexpression correlates with poor prognosis.

Purpose of the Study:

  • To review the therapeutic potential of targeting the transcription factor Yin Yang 1 (YY1) in cancer.
  • To explore YY1's role in epithelial-mesenchymal transition (EMT) and drug resistance.
  • To discuss anti-tumor strategies focused on inhibiting YY1.

Main Methods:

  • Literature review of studies investigating Yin Yang 1 (YY1) in cancer.
  • Analysis of YY1's role in regulating cancer cell survival, proliferation, EMT, and drug resistance.
  • Examination of experimental models targeting YY1 for anti-tumor activity.

Main Results:

  • Overexpression of YY1 is common in many cancers and associated with poor patient outcomes.
  • YY1 plays a key role in promoting EMT, which facilitates cancer cell survival and resistance.
  • Targeting YY1 is hypothesized to inhibit cancer cell survival and proliferation, reverse EMT, and overcome drug resistance.

Conclusions:

  • Yin Yang 1 (YY1) represents a promising therapeutic target for various cancers.
  • Inhibiting YY1 may offer a novel strategy to combat cancer metastasis and drug resistance.
  • Further research into YY1-targeted therapies is warranted to develop effective treatments for metastatic cancers.

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