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Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
Published on: September 13, 2014
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Viral Hepatitis and Acute Liver Failure: Still a Problem
Daniel Sedhom1, Melroy D'Souza1, Elizabeth John1
1Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, 1 Robert Johnson Place, New Brunswick, NJ 08903, USA.
Clinics in Liver Disease
|April 2, 2018
Summary
Viral hepatitis remains a significant cause of acute liver failure globally, despite decreasing overall prevalence. Increased incidence in specific groups highlights the need for continued clinical vigilance and research into novel therapies for hepatitis D and E.
Area of Science:
- Hepatology and Virology
Background:
- Viral hepatitis is a leading global cause of acute liver failure (ALF).
- Hepatitis A, B, D, and E are implicated in the majority of fulminant hepatic viral infections.
- Despite declining overall rates, incidence is rising in certain demographics.
Purpose of the Study:
- To underscore the continued clinical relevance of viral hepatitis in ALF.
- To highlight emerging therapeutic strategies for specific viral hepatitis types.
Main Methods:
- Review of current epidemiological data on viral hepatitis and ALF.
- Analysis of clinical significance and emerging treatment modalities.
Main Results:
- Viral hepatitis remains a critical etiological factor in ALF worldwide.
- Hepatitis D and E are subjects of ongoing therapeutic research, including antivirals and immunotherapies.
- Clinical suspicion for viral etiologies in ALF is crucial, particularly in at-risk populations.
Conclusions:
- Viral hepatitis continues to be a major contributor to acute liver failure.
- Ongoing research into novel treatments for Hepatitis D and E is warranted.
- Clinicians must maintain a high index of suspicion for viral hepatitis in patients presenting with ALF.
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