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Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

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Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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What is the Endocrine System?00:46

What is the Endocrine System?

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The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
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The Endocrine System01:29

The Endocrine System

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The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
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An Overview of the Endocrine System01:10

An Overview of the Endocrine System

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The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
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Structures of the Endocrine System00:59

Structures of the Endocrine System

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The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
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Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

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A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
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In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
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In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

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Endocrine disruptors and testicular function.

Stefania Lymperi1, Aleksander Giwercman2

  • 1Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Metabolism: Clinical and Experimental
|April 2, 2018
PubMed
Summary
This summary is machine-generated.

Concerns about endocrine disruptors (EDs) are rising due to increased production and links to male reproductive issues. Human evidence remains ambiguous, necessitating standardized studies for risk assessment and public health policies.

Keywords:
Anogenital distanceCryptorchidismEndocrine disruptorsHypospadiasMale infertilityTesticular cancerTesticular dysgenesis syndrome

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Area of Science:

  • Environmental Science
  • Toxicology
  • Reproductive Health

Background:

  • Endocrine disruptors (EDs) are man-made chemicals interfering with hormonal balance.
  • Despite scientific concerns, ED production and use have increased.
  • EDs are linked to male reproductive disorders like poor semen quality and congenital defects.

Purpose of the Study:

  • To review the impact of endocrine disruptors on male reproductive health.
  • To highlight the ambiguity of human evidence and factors contributing to it.
  • To emphasize the need for standardized research and public health policies.

Main Methods:

  • Review of existing scientific literature on endocrine disruptors and male reproductive health.
  • Analysis of animal studies and human epidemiological data.
  • Discussion of challenges in establishing causality in human exposure studies.

Main Results:

  • Animal studies show adverse effects of EDs on the male reproductive system.
  • Human evidence remains ambiguous due to complex factors like exposure timing, latency, and genetics.
  • Heterogeneity in human studies hinders consensus on EDs' health risks.

Conclusions:

  • Further research with standardized guidelines is crucial for accurate human health risk assessment.
  • Policies to limit public exposure to endocrine disruptors are necessary.
  • Addressing the impact of EDs on male reproductive health requires a concerted scientific and regulatory effort.