Related Experiment Video
Updated: Feb 12, 2026
08:52
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
3.5K
Inter- and intraobserver repeatability and reproducibility of choroidal thickness measurements using two different
Angelakis Malamas1, Nikolaos Dervenis1, Vasileios Kilintzis1
1Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, St. Kiriakidi 1, 54621, Thessaloniki, Greece.
International Ophthalmology
|April 2, 2018
Summary
Enhanced depth imaging of spectral-domain optical coherence tomography (EDI-OCT) provides highly reproducible choroidal thickness measurements. Both inter- and intraobserver variability were minimal, confirming EDI-OCT
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Choroidal thickness is a key parameter in ocular health.
- Accurate measurement is crucial for diagnosing and monitoring eye diseases.
Purpose of the Study:
- To assess the repeatability and reproducibility of choroidal thickness measurements using enhanced depth imaging of spectral-domain optical coherence tomography (EDI-OCT).
- To evaluate measurement consistency across different observers and sessions with two distinct protocols.
Main Methods:
- Twenty subjects from the Thessaloniki Eye Study database were included.
- Choroidal thickness was measured using EDI-OCT with two protocols.
- Two independent examiners assessed all images across two separate sessions.
Main Results:
- High interobserver intraclass correlation coefficients (ICCs) were observed for average choroidal thickness (0.944) and volume (0.932).
- Intraobserver repeatability ICCs ranged from 0.913 to 0.994, indicating excellent consistency.
- Specific ICCs for central, minimum, and maximum choroidal thickness were also high (0.899, 0.863, 0.955).
Conclusions:
- Choroidal thickness measurements obtained via EDI-OCT demonstrate excellent inter- and intraobserver reproducibility.
- EDI-OCT is a reliable tool for consistent choroidal thickness assessment in clinical practice.
Related Concept Videos
01:15Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs
210
Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
210
01:30Measurement of Bioavailability: Pharmacokinetic Methods
294
Pharmacokinetics is a vital branch of pharmacology that examines how drugs are absorbed, distributed, metabolized, and excreted by the body. Two key methodologies in pharmacokinetics are plasma drug concentration studies and urinary drug excretion analyses, both of which provide critical insights into a drug's therapeutic efficacy and bioavailability.Plasma Drug Concentration-Time StudiesPlasma drug concentration-time studies involve analyzing blood samples at specific intervals to quantify...
294
01:20Measurement of Bioavailability: Pharmacodynamic Methods
844
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
844
01:23Design Example: Deciding Thickness of Lubricating Fluid in a Shaft
347
Effective lubrication between a rotating shaft and its bearing housing is essential in rotating machinery to minimize friction, wear, and energy loss. With carefully controlled thickness and viscosity, the lubricant layer prevents metal-to-metal contact, ensuring smooth operation.
To calculate the required thickness of the lubricant layer, the tangential velocity at the shaft's surface must first be determined. This velocity is calculated by converting the rotational speed to angular velocity...
To calculate the required thickness of the lubricant layer, the tangential velocity at the shaft's surface must first be determined. This velocity is calculated by converting the rotational speed to angular velocity...
347
01:23Microbial Growth Measurement: Direct Methods
1.9K
Direct methods for measuring microbial populations in a culture are essential tools in microbiology, providing quantitative data for various applications. Among these, microscopic counts, plate counts, and serial dilution are widely used techniques, each with unique principles and applications.Microscopic CountsMicroscopic counting involves the use of a Petroff-Hausser chamber, a specialized microscope slide with a grid and defined depth. By observing a liquid culture under a microscope,...
1.9K
01:27Microbial Growth Measurement: Indirect Methods
1.6K
Estimating microbial growth is essential for understanding population dynamics and environmental adaptations. Indirect methods provide valuable insights by measuring parameters such as turbidity, metabolic activity, and biomass, enabling efficient and reproducible assessments.During exponential growth, microbial cells scatter light proportionally to their biomass, a principle used in turbidity measurements. About one million cells per milliliter produce detectable scattering, which a...
1.6K