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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Recommendations for the use of Rituximab in neuromyelitis optica spectrum disorders
J Ciron1, B Audoin2, B Bourre3
1Pôle de neurosciences, department of neurology, hôpital Pierre-Paul-Riquet, university hospital of Toulouse, place du Dr-Baylac, 31059 Toulouse Cedex 9, France; Pôle neurosciences locomoteur, department of neurology, university hospital of Poitiers, 2, rue de la Milétrie, 86021 Poitiers Cedex, France.
Abstract:
There is growing evidence of a preventive effect of Rituximab (RTX) in neuromyelitis optica spectrum disorders (NMO-SD). This monoclonal antibody against CD20 is becoming the most widely used preventive therapy in NMO-SD, as a first-line therapy or as a rescue therapy. Nevertheless, considerable heterogeneity still exists concerning the pre-treatment work-up, the vaccinations required before and under treatment, the number and dosage of infusions, prevention of the risk of infusion-related reactions, prevention of infections under treatment, and frequency of therapeutic cycles. Thanks to a collaborative work among NMO-SD experts belonging to the NOMADMUS project, we provide here recommendations for all these topics concerning RTX use in NMO-SD.
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