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Complement: The Emerging Architect of the Developing Brain.

Liam G Coulthard1, Owen A Hawksworth2, Trent M Woodruff2

  • 1Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; School of Clinical Medicine, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Trends in Neurosciences
|April 3, 2018
PubMed
Summary
This summary is machine-generated.

Complement proteins are crucial for brain development, influencing neuron formation and function. This review highlights their roles in progenitor proliferation, neuronal migration, and synaptic pruning.

Keywords:
complementinnate immunityneural progenitorneurodevelopmentneuronal migrationsynaptic pruning

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Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Biology

Background:

  • Complement activation products traditionally linked to innate immunity.
  • Emerging evidence reveals non-inflammatory roles for complement in the central nervous system.
  • Complement proteins are increasingly recognized for novel functions in brain development.

Purpose of the Study:

  • To review the key roles of complement proteins in the developing brain.
  • To explore the specific functions of complement in neurodevelopmental processes.
  • To synthesize current understanding of complement's involvement in neuronal formation and refinement.

Main Methods:

  • Literature review of studies on complement and brain development.
  • Analysis of research on complement proteins' actions on neurons.
  • Synthesis of findings related to progenitor proliferation, neuronal migration, and synaptic pruning.

Main Results:

  • Complement proteins play distinct physiological roles in neuron development.
  • These roles include influencing progenitor cell proliferation.
  • Complement mediates neuronal migration and synaptic pruning processes.

Conclusions:

  • Complement proteins have critical, non-immune functions in brain development.
  • These proteins are integral to neuronal formation, migration, and synaptic refinement.
  • Further research into complement's neurodevelopmental roles is warranted.