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Colon cleansing protocol in children: research conditions vs. clinical practice
Yoram Elitsur1, Yaslam Balfaqih1, Deborah Preston1
1Joan C Edwards School of Medicine at Marshall University - Pediatrics, Huntington, West Virginia, United States.
Insights
Colon cleansing protocols using PEG-3350 and Dulcolax are effective in routine pediatric colonoscopy. This study confirms the clinical applicability of a previously researched colon preparation method.
Area of Science:
- Pediatric Gastroenterology
- Endoscopic Procedures
- Clinical Practice Research
Background:
- Colon preparation is crucial for successful pediatric colonoscopy.
- Published colon cleansing protocols require evaluation in real-world clinical settings.
- This study assesses a specific colon cleansing protocol in routine practice.
Purpose of the Study:
- To evaluate the success rate of a previously published colon cleansing protocol in routine clinical practice.
- To compare the efficacy of the protocol under research conditions versus clinical practice.
Main Methods:
- Retrospective analysis of a colon cleansing protocol using PEG-3350 and Dulcolax.
- Adequate preparation graded on a 1-5 scale (≥4.0).
- Patient questionnaires collected data on stool output, consistency, and side effects.
Main Results:
- Colon preparation success rates were similar between research (73.6%) and clinical practice (75%).
- Total stools, stool consistency, and terminal ileum intubation rates were comparable.
- The protocol demonstrated effectiveness and appropriateness for routine use.
Conclusions:
- The colon cleansing protocol is effective and applicable in routine clinical practice.
- Testing protocols under routine conditions is recommended to confirm generalizability.
- This validates a specific PEG-3350 and Dulcolax regimen for pediatric colonoscopy.
Background And Study Aims:
Colon preparation rates are the limiting factor for a successful diagnostic colonoscopy in children. Different colon cleansing protocols have been published for use in children. Unfortunately, the applicability of those published research protocols has not been formally evaluated in routine clinical practice. We investigated the success rate of our previously published colon cleansing protocol as utilized in our clinical practice.
Patients And Methods:
This was a retrospective study. In the clinical practice, the colon cleansing protocol included PEG-3350 at a dose of 2 g/kg/day plus Dulcolax (Bisacodyl, Boehringer Ingelheim, TX USA) 5 mg/day for 2 days. Adequate colon preparation was graded between 1 - 5, as previously described, and grade ≥ 4.0 was considered an adequate preparation. Patients were instructed to complete a questionnaire that included PEG-3350 dose, number of stools per day, consistency of each stool, and side effects (vomiting, abdominal pain). Clinical and endoscopic results were compared between the protocol under research conditions and routine practice.
Results:
The success rate of the colon preparation in our clinical practice was similar to the results observed under our research protocol (75 % vs. 73.6 %). Moreover, the total number of stools, stool consistency, and the intubation rate of the terminal ileum were also similar. We concluded, that in our experience, the colon cleansing protocol used under research conditions was effective and appropriate for use in routine clinical practice.
Conclusion:
We recommend testing each new protocol under the routine conditions of clinical practice to confirm its applicability for general practitioners.
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