A nursing theory-guided framework for genetic and epigenetic research

Area of Science:

• Genetics
• Epigenetics
• Human Phenotype

Background:

• The influence of genetics and natural selection on innate traits and human phenotype is a subject of ongoing debate.
• Existing theories on innate traits often lack a contemporary framework to connect with modern genetic and epigenetic research.

Purpose of the Study:

• To examine how innate theory informs current genetic research.
• To offer a contemporary perspective on how innate traits can inform genetic and epigenetic research by integrating Martha Rogers' theory of unitary human beings.
• To propose a novel conceptual model for genetic and epigenetic research.

Main Methods:

• A synthesis of philosophical, theoretical, and research literature.
• Merging conceptual phenomena from innate theory with Rogers' theory of unitary human beings.
• Development of the University of Illinois at Chicago model for genetic and epigenetic research.

Main Results:

• The proposed model positions innate traits as central but acknowledges their epigenetic modification by various determinants.
• Biological, physiological, psychological, and social factors are identified as key epigenetic modifiers.
• These modifiers act as crucial links between innate traits and epigenetic changes, emphasizing individual and environmental interactions.

Conclusions:

• The University of Illinois at Chicago model provides a contemporary framework for understanding the interplay between innate traits and epigenetics.
• The model highlights the dynamic and evolving nature of genetic and epigenetic expression influenced by environmental factors.
• This integrated approach offers a new lens for future genetic and epigenetic research.