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Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons01:03

¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons

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Protons in identical electronic environments within a molecule are chemically equivalent and have the same chemical shift. The replacement test is a useful tool to identify chemical equivalence and predict NMR spectra. A substituent replaces each of the protons being examined and the resulting molecules are compared. If the same molecule is obtained, the protons are equivalent or homotopic. Replacement of any hydrogens in ethane by chlorine yields chloroethane because all six protons are...
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Related Experiment Video

Updated: Feb 12, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
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Heterotopic Ossification Following Hip Arthroscopy.

Matt Barth, Gilbert M Willett, Kimberly Oliphant

    The Journal of Orthopaedic and Sports Physical Therapy
    |April 3, 2018
    PubMed
    Summary

    Early physical therapy after hip surgery may lead to complications. A young woman experienced worsening symptoms and developed heterotopic ossification, a condition of abnormal bone growth, after starting rehabilitation soon post-operation.

    Keywords:
    computed tomographyhiphip arthroscopyradiography

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    Area of Science:

    • Orthopedic Surgery
    • Sports Medicine
    • Physical Therapy

    Background:

    • Hip arthroscopy with labrum debridement and osteochondroplasty is a common procedure for hip joint pathology.
    • Postoperative rehabilitation is crucial for optimal recovery and return to function.
    • The timing and intensity of initiating physical therapy can influence patient outcomes.

    Observation:

    • A 21-year-old female patient began physical therapy 4 days after hip arthroscopic labrum debridement and osteochondroplasty.
    • The patient demonstrated a regression in status during the postoperative rehabilitation period.
    • Persistent symptoms prompted further investigation.

    Findings:

    • A computed tomography scan and radiographs confirmed the development of heterotopic ossification at 10 weeks postsurgery.
    • Heterotopic ossification represents abnormal bone formation in soft tissues, potentially hindering recovery.

    Implications:

    • This case highlights a potential risk associated with early initiation of physical therapy following hip arthroscopic procedures.
    • Clinicians should consider the potential for heterotopic ossification when managing patients post-hip surgery.
    • Further research may be warranted to determine optimal timing and protocols for physical therapy after hip labral debridement and osteochondroplasty.