Related Experiment Video
Updated: Feb 12, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
NADPH-dependent and -independent disulfide reductase systems
Colin G Miller1, Arne Holmgren2, Elias S J Arnér2
1Department of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA; Department of Microbiology & Immunology, Montana State University, Bozeman, MT 59717, USA.
Cellular reducing power, primarily from NADPH, fuels life processes. This summary explores selenium-dependent and independent pathways, including those supporting DNA precursor synthesis by ribonucleotide reductase.
Area of Science:
- Biochemistry
- Molecular Biology
- Cellular Respiration
Background:
- Electron flow (
Purpose of the Study:
- To summarize NADPH-independent disulfide reductase systems.
- Discuss their implications for cellular processes.
Main Methods:
- Literature review of existing studies.
- Analysis of biochemical pathways.
Main Results:
- Nicotinamide adenine dinucleotide-phosphate (NADPH) is a key electron carrier.
- Selenium-dependent enzymes (selenoproteins) are common in metazoan disulfide reduction.
- Ribonucleotide reductase (RNR) requires reducing power for DNA precursor synthesis.
Conclusions:
- While NADPH-dependent systems are universal, NADPH-independent pathways also exist.
- These alternative systems can support essential functions like RNR activity.
More Related Videos
06:15Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
Published on: September 7, 2018
11:35Selection-dependent and Independent Generation of CRISPR/Cas9-mediated Gene Knockouts in Mammalian Cells
Published on: June 16, 2017
Related Concept Videos
Independent and Dependent Sources
Independent voltage or current sources supply a fixed amount of voltage or current, respectively, which is unaffected by other elements within the circuit. These are represented using specific symbols. Independent voltage sources are symbolized with polarities (+ and -), indicating the direction of the...
Introduction to Test of Independence
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
Hypothesis Test for Test of Independence
H0: The two variables (factors)...
Law of Independent Assortment
Temperature Dependence on Reaction Rate
Atoms, molecules, or ions must collide before they can react with each other. Atoms must be close together to form chemical bonds. This premise is the basis for a theory that explains many observations regarding chemical kinetics, including factors affecting reaction rates.
The collision theory is based on the postulates that (i) the reaction rate is proportional to the rate of reactant collisions, (ii) the reacting species collide in an orientation allowing contact between...
Frequency-dependent Selection