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Updated: Feb 12, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
Impact of Lipoproteins on Atherobiology: Emerging Insights
Ma Feng1, Fabiana Rached2, Anatol Kontush1
1National Institute for Health and Medical Research (INSERM), INSERM UMR 1166 ICAN, University of Pierre and Marie Curie - Paris 6, 91 Boulevard de l'Hôpital, Paris 75013, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, 91 Boulevard de l'Hôpital, Paris 75013, France.
Abstract:
Apolipoprotein B-containing lipoproteins and low-density lipoprotein play a key role in atherosclerotic vascular disease. Modified forms of low-density lipoprotein drive inflammation, an integral aspect of plaque progression. High-density lipoprotein particles are equipped to protect low-density lipoprotein from enzymatic and nonenzymatic modification. Under normal conditions, high-density lipoproteins facilitate cholesterol efflux from tissues, preventing its accumulation with deleterious consequences. However, the high-density lipoprotein particles characteristic of dyslipidemic states associated with premature atherosclerosis are typically dysfunctional as a result of alteration in their metabolism and consequently their structure and composition. Such an effect indirectly enhances low-density lipoprotein atherogenicity.
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