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[Persistent asthma: Chronic therapy quantitative compliance in daily practice]
P Devillier1, C Ghasarossian2, P Terrioux3
1UPRES EA 220, hôpital Foch, département des maladies des voies respiratoires, université Paris-Saclay, 11, rue Guillaume-Lenoir, 92150 Suresnes, France.
Revue Des Maladies Respiratoires
|April 4, 2018
Summary
Assessing medication adherence in persistent asthma patients revealed that obesity is linked to poor compliance. Patients with low adherence experienced more severe symptoms and uncontrolled asthma, highlighting the need for better treatment adherence strategies.
Area of Science:
- Pulmonary Medicine
- Clinical Pharmacy
- Epidemiology
Background:
- Persistent asthma requires consistent maintenance treatment for effective management.
- Assessing treatment compliance in real-world clinical practice is crucial for understanding patient outcomes.
Purpose of the Study:
- To evaluate the compliance with maintenance therapy among patients diagnosed with persistent asthma in a clinical setting.
- To identify factors associated with poor adherence and its impact on asthma control.
Main Methods:
- An observational, cross-sectional, prospective, multicenter study involving 488 persistent asthma patients in France.
- Compliance was measured using Health Insurance data (Statement of Consumption) and the Morisky questionnaire.
- Data analysis compared medication consumption against prescriptions and assessed correlations with patient characteristics and asthma control.
Main Results:
- Good compliance (≥80%) was observed in 51% of patients via Statement of Consumption and 38% via Morisky questionnaire.
- Obesity was identified as a significant predictor of poor compliance (19% vs 7%, P<0.05).
- Patients with poor adherence exhibited more severe symptoms and a higher rate of uncontrolled asthma (21.7% vs 5.7%, P<0.01).
Conclusions:
- The Statement of Consumption offers a valuable quantitative measure for assessing medication compliance in routine clinical practice.
- Improving treatment adherence in persistent asthma patients, particularly those who are obese, is essential for better symptom control and disease management.
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