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Common acute lymphoblastic leukemia antigen: partial characterization by in vivo labeling and isolation of its
1Kinderklinik, Abteilung für Hämatologie und Onkologie, Universitätskrankenhaus Eppendorf, Hamburg, Federal Republic of Germany.
Cancer Detection and Prevention. Supplement : Official Publication of the International Society for Preventive Oncology, Inc
|January 1, 1987
Abstract:
Common acute lymphoblastic leukemia (ALL) antigen (CALLA)-like proteins were detected by in vivo labeling experiments carried out with human lymphoblastoid cell line KM3 and also in cell-free translation, directed by CALLA-specific mRNA prepared from immunoadsorbed KM3 polysomes. The CALLA-like structure found in both systems shows an Mr of 95kDa. Additional CALLA-like proteins could be identified in the in vivo experiments with calculated Mrs of 40kDa in the cells and 85 and 38kDa in the culture medium. In the cell-free translation system, an additional product of Mr 80kDa could be detected.