Two new thiophene polyacetylene glycosides from Atractylodes lancea

Area of Science:

• Natural Product Chemistry
• Pharmacology
• Organic Chemistry

Background:

• Atractylodes lancea is a traditional medicinal herb.
• Rhizomes are rich sources of bioactive phytochemicals.
• Thiophene polyacetylene glycosides are a class of compounds with potential biological activities.

Purpose of the Study:

• To isolate and characterize novel compounds from Atractylodes lancea rhizomes.
• To evaluate the anti-inflammatory potential of isolated compounds.

Main Methods:

• Phytochemical investigation using spectroscopic techniques (UV, IR, NMR, HRESIMS).
• Structure elucidation of new compounds via extensive data analysis.
• Determination of absolute configurations using calculated and experimental circular dichroism.
• In vitro biological assay for nitric oxide inhibition in lipopolysaccharide-induced BV2 cells.

Main Results:

• Two new thiophene polyacetylene glycosides (compounds 1 and 2) were isolated.
• Six known compounds (compounds 3-8) were also identified.
• Compounds 3, 7, and 8 demonstrated moderate inhibitory activity against lipopolysaccharide-induced nitric oxide production.

Conclusions:

• The study successfully identified novel thiophene polyacetylene glycosides from Atractylodes lancea.
• Compounds 3, 7, and 8 exhibit potential anti-inflammatory properties.
• Further research is warranted to explore the therapeutic applications of these compounds.