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Integrated transcriptomes throughout swine oestrous cycle reveal dynamic changes in reproductive tissues interacting
Jun-Mo Kim1, Jong-Eun Park2, Inkyu Yoo3
1Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do, 17546, Republic of Korea.
Scientific Reports
|April 5, 2018
Summary
This study reveals key bridging genes regulating female reproductive tissue synchronization during the estrous cycle. Understanding these genomic links is crucial for improving fertility and reproductive health in pigs.
Area of Science:
- Reproductive Biology
- Genomics
- Animal Science
Background:
- Female fertility relies on complex, synchronized tissue activities.
- The genomic regulation governing this synchronization across reproductive tissues remains largely unknown.
Purpose of the Study:
- To investigate the transcriptomic profiles of porcine ovary, endometrium, and oviduct throughout the estrous cycle.
- To identify bridging genes that connect these tissues at a genomic level.
- To elucidate the regulatory mechanisms underlying reproductive tissue synchronization.
Main Methods:
- Transcriptome analysis of ovary, endometrium, and oviduct at multiple time points (Days 0-18) of the estrous cycle.
- Identification and analysis of bridging genes shared across the three tissues.
- Correlation analysis of gene expression levels between tissues.
- Functional annotation of identified bridging genes.
Main Results:
- A network of three interconnected tissue-networks (ovary, endometrium, oviduct) was established.
- Sixty-five bridging genes with high connectivity across all tissues were identified.
- Negative correlations in expression were observed between the ovary and the other two tissues.
- Functional annotations highlighted steroid hormone biosynthesis, cell adhesion, and apoptosis as key processes.
Conclusions:
- Bridging genes play a critical role in synchronizing porcine reproductive tissues during the estrous cycle.
- Steroid hormone biosynthesis and tissue viability are central regulatory mechanisms.
- This research provides a genomic framework for understanding and potentially manipulating female reproductive synchrony.
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