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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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Adoptive T Cell Therapy for Epstein-Barr Virus Complications in Patients With Primary Immunodeficiency Disorders

Lauren P McLaughlin1,2, Catherine M Bollard1,3,4, Michael D Keller1,3

  • 1Center for Cancer and Immunology Research, Children's National Health System, The George Washington University, Washington, DC, United States.

Frontiers in Immunology
|April 5, 2018
PubMed

Patients with primary immunodeficiency disorders (PID) have an increased risk from acute and chronic Epstein-Barr Virus (EBV) viral infections and EBV-associated malignancies. Hematopoietic stem cell transplantation (HSCT) is a curative strategy for many patients with PID, but EBV-related complications are common in the immediate post-transplant period due to delayed reconstitution of T cell immunity. Adoptive T cell therapy with EBV-specific T cells is a promising therapeutic strategy for patients with PID both before and after HSCT. Here we review the methods used to manufacture EBV-specific T cells, the clinical outcomes, and the ongoing challenges for future development of the strategy.

Keywords:
Epstein–barr virusadoptive T cell therapyhematopoietic stem cell transplantationimmunotherapyprimary immunodeficiency disorders

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