Related Experiment Video
Updated: Feb 12, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
Published on: November 2, 2019
Single Lymphaticovenular Anastomosis for Early-Stage Lower Extremity Lymphedema Treated by the
Yukio Seki1, Akiyoshi Kajikawa1, Takumi Yamamoto1
1Department of Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Kanagawa, Japan; Department of Plastic and Reconstructive Surgery, Shonan Atsugi Hospital, Kanagawa, Japan; and Department of General Surgery, Shonan Atsugi Hospital, Kanagawa, Japan.
A single lymphaticovenular anastomosis (LVA) using a superior-edge-of-the-knee incision effectively treated lower extremity lymphedema (LEL). This method showed significant reduction in lymphedema volume for patients with stage 2 or 3 dermal backflow.
Area of Science:
- Vascular Surgery
- Lymphedema Management
- Microsurgery
Background:
- Surgical treatment for lower extremity lymphedema (LEL) presents significant challenges.
- The superior-edge-of-the-knee incision for lymphaticovenular anastomosis (LVA) enhances lymph-to-venous flow, leveraging knee movement during ambulation.
- This study evaluates the efficacy of a single LVA using this specific incision for early-stage LEL.
Purpose of the Study:
- To assess the therapeutic effectiveness of a single lymphaticovenular anastomosis (LVA) in patients with early-stage lower extremity lymphedema (LEL).
- To determine if the superior-edge-of-the-knee incision method is adequate for treating stage 2 and 3 LEL.
Main Methods:
- The study included 10 patients diagnosed with stage 2 or 3 LEL and leg dermal backflow.
- A single lymphaticovenular anastomosis (LVA) was performed at the thigh using the superior-edge-of-the-knee incision.
- Intraoperative assessment of lymphatic vessels and flow direction, followed by postoperative evaluation of lymphedema volume reduction.
Main Results:
- The superior-edge-of-the-knee incision facilitated a single anastomosis in all patients, irrespective of LEL stage (stage 2 or 3).
- No instances of venous reflux were observed post-procedure.
- A mean reduction in the lower extremity lymphedema index of 20.160% was achieved after a mean follow-up of 7.70 months.
Conclusions:
- A single lymphaticovenular anastomosis (LVA) performed with the superior-edge-of-the-knee incision method demonstrates significant therapeutic potential.
- This surgical approach is effective for managing patients with stage 2 or 3 leg dermal backflow in lower extremity lymphedema.
- The method offers a promising solution for challenging LEL cases.
Related Concept Videos
Knee Joint
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
Absolute and Local Extreme Values
Stages of Infection
Cranial Bones: Superior and Posterior View
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
Stages of Sleep
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Stages of General Anesthesia

