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Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
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Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
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Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
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Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
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Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
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Related Experiment Video

Updated: Feb 12, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
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Specific Transcriptome Changes Associated with Blood Pressure Reduction in Hypertensive Patients After Relaxation

Manoj K Bhasin1,2,3, John W Denninger1,4, Jeff C Huffman4

  • 11 Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital , Boston, MA.

Journal of Alternative and Complementary Medicine (New York, N.Y.)
|April 5, 2018
PubMed
Summary

Mind-body practices that activate the relaxation response (RR) can lower blood pressure (BP) in hypertension (HTN). This study identified key molecular pathways, including immune regulation and metabolism, linked to RR

Keywords:
blood pressuregene expressionhypertensionmicroarraymindfulnessrelaxation response

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Area of Science:

  • Cardiovascular Research
  • Genomics
  • Integrative Medicine

Background:

  • Mind-body practices eliciting the relaxation response (RR) show potential in reducing blood pressure (BP) for essential hypertension (HTN).
  • The precise molecular mechanisms underlying RR's antihypertensive effects remain largely unknown.
  • Understanding these mechanisms could enhance RR as an adjunct therapy to conventional treatments.

Purpose of the Study:

  • To identify genomic determinants associated with responsiveness to an 8-week RR-based mind-body intervention in patients with stage 1 hypertension.
  • To elucidate the molecular pathways and cellular changes involved in blood pressure reduction through RR.

Main Methods:

  • Genomic analysis of peripheral blood mononuclear cells from hypertensive patients classified as BP responders or non-responders to an RR intervention.
  • Transcriptome analysis to identify differentially expressed genes.
  • In silico estimation of immune cell abundance and network analysis of key molecular interactions.

Main Results:

  • Identified 1771 genes regulated by RR in BP responders.
  • Enrichment of immune regulatory pathways, metabolism, glucose metabolism, cardiovascular development, and circadian rhythm pathways.
  • BP responders showed increased M2 macrophage subtypes and highlighted the roles of nuclear factor-κB, vascular endothelial growth factor, and insulin.

Conclusions:

  • These findings offer novel insights into the molecular mechanisms underlying the blood pressure-lowering effects of the relaxation response.
  • The study suggests a link between RR, immune modulation, metabolic changes, and cardiovascular health in hypertension.
  • Further research into these molecular pathways could optimize mind-body interventions for hypertension management.