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Area of Science:

  • Oncology
  • Metabolic Syndrome
  • Inflammation Research

Background:

  • The roles of obesity, metabolic dysregulation, and systemic inflammation in prostate carcinogenesis remain unclear.
  • High-grade prostatic intraepithelial neoplasia (HGPIN) is a precursor lesion to prostate cancer (PC).

Purpose of the Study:

  • To investigate metabolic and inflammatory factors influencing the transition from HGPIN to PC.
  • To assess the association of metabolic dysregulation and systemic inflammation with PC risk in HGPIN patients.

Main Methods:

  • Prospective follow-up of 160 men diagnosed with HGPIN.
  • Analysis of metabolic factors including BMI, waist circumference, and medication use (NSAIDs, statins, metformin).
  • Measurement of 13 plasma cytokine levels to estimate systemic inflammation.

Main Results:

  • Statin use was significantly associated with a reduced risk of overall PC detection (OR=0.45).
  • A stronger association was observed for high-grade PC (OR=0.39) compared to low-grade PC (OR=0.50).
  • Metabolic factors (BMI, WHR, diabetes, hypertension) and inflammatory markers were not significantly linked to PC risk.

Conclusions:

  • Statin use is significantly associated with a reduced risk of prostate cancer detection in men with HGPIN.
  • Systemic inflammation markers did not mediate the observed association between statins and lower PC risk.
  • Statins may influence prostate cancer progression through alternative, non-inflammatory pathways.