Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Initiation of Translation02:33

Initiation of Translation

39.2K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.2K
Translation01:31

Translation

157.3K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
157.3K
Translation01:31

Translation

18.0K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
18.0K
Psychology as a Science01:13

Psychology as a Science

4.0K
Psychology, as a scientific discipline, aims to understand the mind and behavior through rigorous and systematic methods. The foundation of psychological research is evidence-based, relying heavily on the scientific method to derive and validate knowledge. This structured approach ensures that findings are reliable, valid, and applicable to broader contexts.
The scientific method in psychology involves six critical steps: making observations, formulating hypotheses, conducting tests, analyzing...
4.0K
Review and Preview01:10

Review and Preview

8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

11.6K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Artificial Intelligence (AI) paradox.

Bioinformation·2026
Same author

Risk group-4 virus emergent threats.

Bioinformation·2025
Same author

Regulation of inflammaging.

Bioinformation·2025
Same author

Protein disorder - function paradigm: Putative role in inflammation.

Bioinformation·2025
Same author

Artificial intelligence in systemic diagnostics: Applications in psychiatry, cardiology, dermatology and oral pathology.

Bioinformation·2025
Same author

Evaluation of rapid detection methods for H5N1 virus using biosensors: An AI-based study.

Bioinformation·2025

Related Experiment Video

Updated: Feb 12, 2026

Using Generative Art to Convey Past and Future Climate Transitions
06:10

Using Generative Art to Convey Past and Future Climate Transitions

Published on: March 31, 2023

1.5K

Quantitative Consensus in Systematic Reviews: Current and Future Challenges in Translational Science.

Francesco Chiappelli1,2,3,4, Vandan R Kasar5, Nicole Balenton1,3

  • 1Laboratory of Human Psychoneuroendocrine-Osteoimmunology; School of Dentistry, UCLA Center for the Health Sciences, Los Angeles, CA 90095-1668.

Bioinformation
|April 6, 2018
PubMed
Summary

Translational science integrates research into patient care, focusing on evidence-based practice. This involves systematic reviews and meta-analysis using Bayesian models to synthesize evidence for improved healthcare guidelines.

Keywords:
Bayesian statisticsPICOTS questionTranslational scienceadditive meta-analysiscomplex systematic reviewsmeta-analysisresearch synthesis

More Related Videos

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
10:12

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications

Published on: April 21, 2023

3.7K
Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

10.5K

Related Experiment Videos

Last Updated: Feb 12, 2026

Using Generative Art to Convey Past and Future Climate Transitions
06:10

Using Generative Art to Convey Past and Future Climate Transitions

Published on: March 31, 2023

1.5K
Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
10:12

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications

Published on: April 21, 2023

3.7K
Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

10.5K

Area of Science:

  • Healthcare research
  • Translational science
  • Evidence-based medicine

Background:

  • Translational science bridges the gap between laboratory research and clinical practice.
  • Current healthcare models emphasize effectiveness, patient-centeredness, and evidence-based decision-making.

Purpose of the Study:

  • To outline the processes within translational science for healthcare improvement.
  • To highlight the role of systematic reviews and meta-analysis in synthesizing evidence.

Main Methods:

  • Research synthesis protocols within comparative effectiveness research.
  • Dissemination through systematic reviews.
  • Quantitative consensus using meta-analysis and Bayesian statistical models.

Main Results:

  • Systematic reviews generate qualitative and quantitative consensus on best evidence.
  • Meta-analysis, often employing Bayesian approaches, provides quantitative consensus.
  • Evidence synthesis informs practice-based guideline revisions.

Conclusions:

  • Translational science is a structured process for evidence-based healthcare.
  • Bayesian meta-analysis is a key tool for quantitative evidence synthesis.
  • This approach supports the continuous improvement of clinical practice guidelines.