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Can targeting ANGPTL proteins improve glucose tolerance?

Brandon S J Davies1

  • 1Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, and Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA, 52242, USA. Brandon-davies@uiowa.edu.

Diabetologia
|April 6, 2018
PubMed
Summary

Reducing angiopoietin-like 4 (ANGPTL4) and angiopoietin-like 8 (ANGPTL8) levels improves glucose tolerance and increases fat mass. This suggests targeting ANGPTL proteins may benefit metabolic health.

Keywords:
DiabetesGut microbiotaInsulin sensitivityLipolysisLipoprotein lipaseLipoproteins

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