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Related Experiment Videos

Anticholinergics and cough.

T W Higenbottam1

  • 1Regional Respiratory Physiology Department, Papworth Hospital, Cambridge, UK.

Postgraduate Medical Journal
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Ultrasonically nebulized aerosols help study human vagal receptors. Bronchodilatation inhibits cough, suggesting pulmonary stretch receptors modulate the human cough reflex.

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Area of Science:

  • Pulmonary physiology
  • Neuroscience
  • Respiratory medicine

Background:

  • Vagal epithelial rapidly adapting receptors (RARs) are involved in respiratory reflexes.
  • The role of these receptors in human cough reflex is not fully understood.
  • Previous studies in animals suggested a role for pulmonary stretch receptors in cough modulation.

Purpose of the Study:

  • To investigate the role of vagal epithelial rapidly adapting receptors in the human cough reflex.
  • To determine if bronchodilatation affects cough induced by low chloride aerosols.
  • To explore the potential involvement of pulmonary stretch receptors in modulating cough.

Main Methods:

  • Ultrasonic nebulization of aqueous aerosols to stimulate vagal receptors.
  • Inhalation of low chloride ion concentration aerosols to induce cough.

Related Experiment Videos

  • Administration of bronchodilators (fenoterol or ipratropium) to assess their effect on cough reflex.
  • Observation of cough response in normal human subjects.

    • Main Results:

    • Inhalation of low chloride aerosols successfully induced cough in human subjects.
    • Bronchodilatation achieved through inhaled fenoterol or ipratropium significantly inhibited the induced cough reflex.
    • The observed inhibition suggests a modulatory role for pulmonary receptors.

    Conclusions:

    • Ultrasonically nebulized aerosols provide a method to study vagal receptors in humans.
    • Pulmonary stretch receptors (slowly adapting receptors) may play a role in modulating the human cough reflex.
    • Findings support previous animal studies suggesting a link between stretch receptors and cough modulation.