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Updated: Feb 12, 2026
Murine Renal Transplantation Procedure
Published on: July 10, 2009
A CLADOPHIALOPHORA BRAIN ABSCESS IN A RENAL TRANSPLANT RECIPIENT
Abstract:
Cladophialophora bantiana is a dematiceous fungus with neurotrophic propensity for which therapy is not standardized and mortality is high. We report here a 49 year old non-diabetic renal transplant patient on triple immunosuppressant therapy who presented with a history of falls, weakness and headaches. A computed tomography scan of the brain revealed a 30 mm diameter abscess in the brain which was removed surgically and diagnosed on culture as C. bantiana. The patient was successfully treated medically post-operatively with chronic posaconazole. We review the literature regarding central nervous system infections due to C. bantiana.
Insights
Cladophialophora bantiana, a fungus causing brain abscesses, has high mortality. This case highlights successful treatment with posaconazole after surgical removal of a brain abscess in an immunosuppressed patient.
Area of Science:
- Mycology
- Infectious Diseases
- Neurosurgery
Background:
- Cladophialophora bantiana is a dematiaceous fungus known for its neurotropic potential.
- Central nervous system infections caused by C. bantiana are rare but associated with high mortality rates.
- Standardized therapeutic guidelines for C. bantiana infections are lacking.
Purpose of the Study:
- To report a case of successful management of a C. bantiana brain abscess in an immunocompromised patient.
- To review the current literature on C. bantiana central nervous system infections.
Main Methods:
- A case study of a 49-year-old renal transplant patient presenting with neurological symptoms.
- Surgical excision of a brain abscess.
- Post-operative treatment with posaconazole.
- Comprehensive literature review on C. bantiana CNS infections.
Main Results:
- A 30 mm brain abscess was surgically removed and diagnosed as C. bantiana.
- The patient experienced a successful recovery following chronic posaconazole therapy.
- Literature review identified limited treatment options and high mortality associated with C. bantiana CNS infections.
Conclusions:
- Early diagnosis and surgical intervention are crucial for managing C. bantiana brain abscesses.
- Chronic posaconazole administration can be an effective treatment strategy.
- Further research is needed to establish standardized treatment protocols for C. bantiana CNS infections.
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