Related Experiment Video
Updated: Feb 12, 2026
09:57
Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster
Published on: March 14, 2019
11.4K
Viral infections in wheezing disorders.
1Faculty of Health and Medical Sciences, Dept of Respiratory Medicine, Child and Adolescent Health Service, University of Western Australia, Perth, Australia peter.lesouef@uwa.edu.au.
Summary
New research explores how respiratory viruses cause wheezing in children and tests interventions like antibodies and bacterial lysates to prevent asthma. Studies show promise for reducing wheezing exacerbations and potentially preventing childhood asthma.
Area of Science:
- Pediatric Respiratory Medicine
- Immunology
- Virology
Background:
- Virus-induced wheeze is a significant concern in children.
- Rhinovirus-C (RV-C) infection is linked to decreased CDHR3 and interferon-β, favoring viral replication.
- Novel interventions are being investigated to manage wheezing exacerbations.
Purpose of the Study:
- To review recent advancements in understanding virus-induced wheeze mechanisms.
- To summarize findings on novel therapeutic interventions for wheezing in children.
- To highlight the potential of bacterial lysates in preventing childhood asthma.
Main Methods:
- Review of recent studies on respiratory virus mechanisms in children.
- Analysis of clinical trial data for anti-viral antibodies, anti-immunoglobulin E therapy, and prednisolone.
- Examination of research on bacterial lysates for immunomodulation.
Main Results:
- RV-C infection is associated with reduced CDHR3 and interferon-β expression.
- Anti-RSV and anti-IgE therapies decreased wheezing exacerbations.
- Prednisolone efficacy in RV-induced wheeze was dependent on viral load (>7000 copies·mL⁻¹).
- Bacterial lysates show potential for reducing virus-induced wheezing.
Conclusions:
- Understanding virus-induced wheeze mechanisms is advancing.
- Several interventions show promise in reducing wheezing exacerbations.
- Bacterial lysates are a promising avenue for preventing childhood asthma, with a large study now underway.
Related Concept Videos
00:57Viral Recombination
25.2K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.2K
00:56Viral Structure
74.8K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.8K
02:18Intrinsically Disordered Proteins
19.6K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
01:29Bone Disorders
5.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.5K
01:27Disorders of Erythrocytes
2.3K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.3K
01:27Disorders of Leukocytes
2.0K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.0K