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Recent Advances: Decoding Alzheimer's Disease With Stem Cells
Yi Fang1, Ting Gao1, Baorong Zhang1
1Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Abstract:
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that destroys cognitive functions. Recently, a number of high-profile clinical trials based on the amyloid cascade hypothesis have encountered disappointing results. The failure of these trials indicates the necessity for novel therapeutic strategies and disease models. In this review, we will describe how recent advances in stem cell technology have shed light on a novel treatment strategy and revolutionized the mechanistic investigation of AD pathogenesis. Current advances in promoting endogenous neurogenesis and transplanting exogenous stem cells from both bench research and clinical translation perspectives will be thoroughly summarized. In addition, reprogramming technology-based disease modeling, which has shown improved efficacy in recapitulating pathological features in human patients, will be discussed.
Insights
Stem cell technology offers new Alzheimer's disease (AD) treatments and research models. Advances in neurogenesis and stem cell transplantation are revolutionizing AD pathogenesis investigation and potential therapies.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Biotechnology
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder impacting cognition.
- Recent clinical trials targeting the amyloid cascade hypothesis have yielded disappointing outcomes.
- This necessitates novel therapeutic strategies and improved disease models for AD research.
Purpose of the Study:
- To review recent advances in stem cell technology for Alzheimer's disease.
- To explore stem cell-based therapeutic strategies and mechanistic investigations of AD.
- To discuss the potential of stem cell transplantation and reprogramming technology in AD research.
Main Methods:
- Summarizing current research on promoting endogenous neurogenesis.
- Reviewing studies on exogenous stem cell transplantation in AD models.
- Discussing the application of reprogramming technology for AD disease modeling.
Main Results:
- Stem cell technology provides novel therapeutic avenues for AD.
- Advances in stem cell research are revolutionizing the understanding of AD pathogenesis.
- Reprogramming technology offers more effective human-centric AD disease models.
Conclusions:
- Stem cell-based approaches represent a promising frontier for Alzheimer's disease treatment and research.
- Further investigation into endogenous and exogenous stem cell strategies is warranted.
- Reprogramming technology-derived models show significant potential for recapitulating AD pathology.