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Testosterone Replacement, Muscle Strength, and Physical Function.

You Seon Nam1, Gyeongsil Lee2, Jae Moon Yun2

  • 1Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea.

The World Journal of Men'S Health
|April 7, 2018
PubMed
Summary

Testosterone replacement therapy does not significantly improve muscle strength in older men. However, it may enhance physical function, warranting further research in diverse populations.

Keywords:
AgedMuscle strengthPhysical activityTestosterone

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Area of Science:

  • Gerontology
  • Endocrinology
  • Sports Medicine

Background:

  • Aging is associated with declines in muscle strength, physical function, and testosterone levels in men.
  • The efficacy of testosterone replacement therapy (TRT) in mitigating these age-related declines is debated, with existing evidence being inconclusive.
  • Understanding TRT's impact is crucial for maintaining healthspan in aging populations.

Purpose of the Study:

  • To systematically review the current evidence on the effects of testosterone replacement therapy on muscle strength and physical function in older men.
  • To synthesize findings regarding specific measures of muscle strength and physical performance.
  • To identify gaps in the existing literature, particularly concerning ethnic diversity.

Main Methods:

  • A rapid systematic review methodology was employed.
  • Studies investigating the impact of TRT on muscle strength (hand grip, leg strength) and physical function (6-minute walk test, Physical Activity Scale for the Elderly) were included.
  • Data synthesis focused on summarizing the reported effects of TRT.

Main Results:

  • Testosterone replacement therapy demonstrated no significant effect on muscle strength parameters.
  • A potential positive effect of TRT was observed on measures of physical function.
  • Most included studies originated from Western countries (US/Europe), limiting generalizability.

Conclusions:

  • Current evidence suggests TRT does not enhance muscle strength but may improve physical function in older men.
  • The lack of ethnic diversity in study populations necessitates further research.
  • Future studies should aim to include a broader demographic range to ascertain TRT's effects across different ethnicities.