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Published on: August 6, 2019
Acaulins A and B, Trimeric Macrodiolides from Acaulium sp. H-JQSF
Ting Ting Wang1,2, Ying Jie Wei3, Hui Ming Ge1
1State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules , Nanjing University , Nanjing 210023 , China.
Abstract:
Acaulin A (1) and its macrolactone ring-opened congener acaulin B (2) were characterized from the culture of Acaulium sp. H-JQSF (an isopod-associated fungus) as architecturally undescribed trimeric macrodiolides, with the former being antiosteoporotic at 0.4 μM in the prednisolone-induced osteoporotic zebrafish. Identification of acaudiolic acid (3) as the monomeric macrodiolide precursor facilitated the proposal of the acaulin biosynthetic pathway.
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