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Relationship between bone remodeling and metabolism in the elderly
Lourdes Basurto-Acevedo1, Renata Saucedo-García, Ana Vázquez-Martínez
1Instituto Mexicano del Seguro Social, Coordinación de Investigación en Salud, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Unidad de Investigación Médica en Enfermedades Endócrinas. Ciudad de México, México lbasurtoa@yahoo.com
Revista Medica Del Instituto Mexicano Del Seguro Social
|April 7, 2018
Summary
Osteocalcin (OC) levels in elderly men negatively correlate with body mass index, waist circumference, glucose, and insulin. This suggests a link between bone health and energy metabolism in older adults.
Area of Science:
- Endocrinology
- Metabolic Health
- Bone Metabolism
Background:
- Emerging research indicates osteocalcin (OC) influences both bone and energy metabolism.
- Understanding the relationship between OC, metabolic factors, and bone mineral density (BMD) is crucial for elderly men's health.
Purpose of the Study:
- To investigate the association between osteocalcin (OC) levels and metabolic parameters.
- To examine the relationship between OC and bone mineral density (BMD) in elderly men.
Main Methods:
- Cross-sectional study involving 122 healthy men aged 60+.
- Measurement of serum glucose, lipids, insulin, adiponectin, and OC.
- Bone mineral density (BMD) assessment via dual-energy X-ray absorptiometry.
Main Results:
- Osteocalcin (OC) concentrations showed inverse correlations with body mass index (BMI), waist circumference, glucose, insulin, and HOMA-IR.
- Men with diminished bone mineral density (BMD) exhibited higher OC levels compared to those with normal BMD.
- No significant difference in OC levels was observed between men with and without metabolic syndrome (MetS).
Conclusions:
- Osteocalcin (OC) levels are negatively associated with key metabolic factors including BMI, waist circumference, glucose, insulin, and HOMA-IR in elderly men.
- Findings suggest a significant interplay between bone metabolism and energy metabolism in this demographic.
- Further research is warranted to elucidate the precise mechanisms underlying these associations.
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