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Updated: Feb 12, 2026
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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
Published on: July 27, 2017
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Pipped at the Post: Pipecolic Acid Derivative Identified as SAR Regulator
1Department of Plant Pathology and Microbiology and Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX 77843, USA.
Cell
|April 7, 2018
Summary
Pipecolic acid (Pip) is crucial for plant immunity. A new study reveals that N-hydroxypipecolic acid (NHP), derived from Pip, acts as a key metabolic regulator for systemic acquired resistance (SAR) in Arabidopsis plants.
Area of Science:
- Plant Biology
- Biochemistry
- Molecular Biology
Background:
- Pipecolic acid (Pip) is a non-protein amino acid derived from lysine metabolism.
- Pip plays a role in plant systemic acquired resistance (SAR), a crucial defense mechanism against pathogens.
Purpose of the Study:
- To elucidate the metabolic pathway and regulatory role of pipecolic acid (Pip) in plant systemic acquired resistance (SAR).
- To identify the specific metabolite derived from Pip that regulates SAR in Arabidopsis.
Main Methods:
- Utilized biochemical assays to investigate the conversion of Pip.
- Employed genetic and molecular techniques in Arabidopsis to study SAR regulation.
Main Results:
- Demonstrated that a flavin-dependent monooxygenase catalyzes the conversion of Pip to N-hydroxypipecolic acid (NHP).
- Showed that NHP is a critical metabolic regulator of SAR in Arabidopsis.
Conclusions:
- The conversion of Pip to NHP is a key regulatory step in activating plant systemic acquired resistance.
- NHP represents a novel metabolic target for understanding and potentially enhancing plant immunity.
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