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Updated: Feb 12, 2026
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Murine Fetal Echocardiography
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Sending Cancer into the Fetal Position
Hannah A Pizzato1, Deepta Bhattacharya2
1Division of Biological and Biomedical Sciences, Washington University in St. Louis, Saint Louis, MO 63110, USA; Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Cell Stem Cell
|April 7, 2018
Summary
Cancer cells can renew themselves and express proteins linked to embryonic development. Researchers found that vaccinating mice with inactivated induced pluripotent stem cells (iPSCs) created T-cell immunity against embryonic antigens, offering protection against various cancers.
Area of Science:
- Oncology
- Immunology
- Stem Cell Biology
Background:
- Malignant cells exhibit self-renewal capabilities.
- Cancer cells can re-express proteins typically found during embryonic development.
Purpose of the Study:
- To investigate the potential of targeting embryonic antigens in cancer therapy.
- To determine if vaccination with induced pluripotent stem cells (iPSCs) can elicit anti-cancer immunity.
Main Methods:
- Mice were vaccinated with syngeneic inactivated induced pluripotent stem cells (iPSCs).
- T-cell responses against embryonic antigens were assessed.
- Cancer resistance was evaluated in vaccinated mice against different cancer types.
Main Results:
- Vaccination with inactivated iPSCs successfully generated T-cell immunity.
- This immunity was directed against key embryonic antigens.
- Vaccinated mice demonstrated resistance to multiple types of induced cancers.
Conclusions:
- Targeting embryonic antigens via iPSC-based vaccination is a viable strategy for cancer immunotherapy.
- This approach may offer broad-spectrum resistance against various malignancies.
- Further research into iPSC-based cancer vaccines is warranted.
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