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Therapeutics incorporating blood constituents
Phapanin Charoenphol1, Katie Oswalt2, Corey J Bishop3
1Department of Mechanical Engineering, Texas A&M University, Mechanical Engineering Building, 202 Spence St., College Station, TX 77843, USA.
Acta Biomaterialia
|April 8, 2018
Summary
This review highlights advancements in blood-based therapeutics, including engineered blood components and biomimetic carriers. It covers progress in synthetic blood substitutes, cell-based therapies, and acellular treatments for various medical conditions.
Area of Science:
- Biomedical Engineering
- Hematology
- Regenerative Medicine
Background:
- Blood disorders and dysfunctionality necessitate treatments like transfusions.
- Blood components can be engineered at cellular and sub-cellular levels to enhance therapeutic effects.
- Recent years have seen significant progress in blood-based therapeutic applications.
Purpose of the Study:
- To review the latest advancements in blood-based therapeutics.
- To emphasize recent applications in blood transfusion, cell-based therapies, and biomimetic carriers.
- To discuss clinically translated technologies and future prospects.
Main Methods:
- Literature review of blood-based therapeutics.
- Focus on synthetic blood substitutes, acellular/non-recombinant therapies, cell-based therapies, and therapeutic sub-components.
- Analysis of pre-clinical and clinically-translated treatments.
Main Results:
- Blood constituents are engineered using DNA recombinant technology and cellular hitchhiking.
- Applications include supplementing efficacy, enhancing drug delivery, and rectifying clotting dysfunction.
- Progress spans synthetic blood substitutes, acellular therapies, cell-based therapies, and therapeutic sub-components.
Conclusions:
- Blood-based therapeutics represent a rapidly advancing field with broad clinical potential.
- Engineered blood components and biomimetic carriers offer promising therapeutic strategies.
- Further research and development are crucial for overcoming challenges and realizing future prospects.
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