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Related Experiment Video

Updated: Feb 12, 2026

Routine Screening Method for Microparticles in Platelet Transfusions

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Development of electrosprayed mucoadhesive chitosan microparticles.

Jorge Alberto S Moreno¹, Ana C Mendes¹, Karen Stephansen¹

¹Nano-Bio Science Research Group, DTU Food, Technical University of Denmark, Kemitorvet 202, 2800 Kgs, Lyngby, Denmark.

Carbohydrate Polymers

|April 10, 2018

Summary

Stable, mucoadhesive chitosan (CS) electrosprayed particles were developed for oral drug delivery. Low molecular weight CS in an acetic acid-ethanol mixture yielded optimal particle size and zeta potential, confirming mucoadhesion.

Keywords:

Chitosan Electrohydrodynamics Electrospray Microparticles Mucoadhesion Polysaccharide

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Area of Science:

Materials Science
Pharmaceutical Sciences
Biotechnology

Background:

Chitosan (CS) is a known drug delivery carrier.
Limited research exists on stable, mucoadhesive CS electrosprayed particles for oral delivery.

Purpose of the Study:

To produce stable and mucoadhesive chitosan electrosprayed particles for oral drug delivery.
To investigate the impact of chitosan properties and solvent composition on particle characteristics.

Main Methods:

Electrospraying of various chitosan types with differing molecular weights (MW), degrees of deacetylation (DD), and degrees of polymerization (DP).
Assessment of solvent composition effects on particle formation.
Characterization of particle size using dynamic light scattering and zeta potential measurements.

Main Results:

Stable chitosan electrosprayed particles were successfully produced using 3% w/v low MW CS in a 50/50% v/v aqueous acetic acid and ethanol mixture.
Particles exhibited an average diameter of approximately 1 μm.
A zeta potential of approximately 40 mV indicated significant mucoadhesion properties.

Conclusions:

Low molecular weight chitosan in a specific acetic acid-ethanol solvent system is effective for creating stable, mucoadhesive electrosprayed particles.
These particles demonstrate potential as a viable carrier for oral drug delivery systems.
The study provides a foundation for developing advanced chitosan-based oral drug formulations.