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Review: Management of patients with kidney allograft failure

Kim L W Bunthof1, Marc Hazzan2, Luuk B Hilbrands1

  • 1Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.

Transplantation Reviews (Orlando, Fla.)
|April 10, 2018
PubMed

Insights

Managing kidney transplant recipients with a failed allograft presents challenges. This review discusses dilemmas in dialysis initiation, immunosuppression, and nephrectomy, highlighting the need for more research.

Area of Science:

  • Nephrology
  • Transplantation Immunology

Background:

  • Late allograft loss is a frequent complication in kidney transplant recipients.
  • Failed kidney allografts are linked to increased patient mortality and morbidity.

Purpose of the Study:

  • To review current evidence and identify knowledge gaps in managing patients with failed kidney allografts.
  • To discuss key management dilemmas including dialysis, immunosuppression, and nephrectomy.

Main Methods:

  • Literature review of current evidence.
  • Discussion of unresolved issues in kidney allograft failure management.

Main Results:

  • Management decisions for failed kidney allografts involve complex choices.
  • Optimal strategies for immunosuppression and timing of interventions remain unclear.

Conclusions:

  • Significant knowledge gaps persist in the management of failed kidney allografts.
  • Further research is essential to optimize patient care and outcomes after kidney transplant failure.

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