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A lesson for site-selective C-H functionalization on 2-pyridones: radical, organometallic, directing group and steric
1Department of Applied Chemistry , Graduate School of Engineering , Osaka University , Suita , Osaka 565-0871 , Japan . Email: k_hirano@chem.eng.osaka-u.ac.jp ;
Abstract:
A 2-pyridone ring is a frequently occurring subunit in natural products, biologically active compounds, and pharmaceutical targets. Thus, the selective synthesis of substituted 2-pyridone derivatives through decoration and/or formation of pyridone rings has been one of the important longstanding subjects in organic synthetic chemistry. This minireview focuses on recent advances in site-selective C-H functionalization on 2-pyridone. The reported procedures are categorized according to the site selectivity that is achieved, and the substrate scope, limitations, mechanism, and controlling factors are briefly summarized.
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