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Continuous, high-dose progestogen treatment of endometrial cancer
Z Szarvas1, B Zsolnai, G Gimes
1Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary.
Gynecologic and Obstetric Investigation
|January 1, 1987
Abstract:
The morphological effect of a high-dose progestogen (Depo-Provera) on highly differentiated endometrial carcinoma was studied. Thirteen patients were treated by progestogen only, given at the beginning of the treatment in a weekly dose of 1,000 mg for 3 month. Then, progestogen 500 mg was administered for 12 months. Nine patients were operated after the treatment; in 7 of them, a total histological regression was observed. Histological tests of the intraoperatively gained preparations showed 'disappearance' of the original carcinomatous process; only a serious atrophy of the endometrium could be detected.