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Updated: Feb 12, 2026
07:32
Porcine Normothermic Isolated Liver Perfusion
Published on: June 9, 2023
1.5K
Normothermic liver preservation, current status and future directions
Danielle Detelich1, James F Markmann
1Department of Transplantation, Massachusetts General Hospital, Boston, Massachusetts, USA.
Current Opinion in Organ Transplantation
|April 10, 2018
Summary
Normothermic machine perfusion (NMP) aids liver preservation by assessing graft viability and enabling interventions. This technology shows promise for improving transplant logistics and outcomes, though large trials are needed.
Area of Science:
- Transplantation science
- Organ preservation technologies
Background:
- Normothermic machine perfusion (NMP) is an emerging technology for liver preservation.
- Early clinical results show NMP benefits in reconditioning high-risk liver grafts.
Purpose of the Study:
- To review the role of NMP in assessing graft viability.
- To discuss NMP as a platform for graft intervention and modification during preservation.
Main Methods:
- Review of current literature on NMP in liver preservation.
- Analysis of early clinical and preclinical study findings.
Main Results:
- NMP shows beneficial effects in reconditioning high-risk liver grafts.
- Pilot studies identified clinically relevant viability criteria for NMP.
- Preclinical studies suggest NMP can extend preservation periods and facilitate graft-targeted interventions.
Conclusions:
- NMP is a multifunctional tool with transformative potential in liver preservation and transplantation.
- Large clinical trials are required to optimize NMP protocols, define indications, and establish its standard use.
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