Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Routes of Persuasion02:20

Routes of Persuasion

68.8K
Persuasion is the process of changing our attitude toward something based on some kind of communication. Much of the persuasion we experience comes from outside forces. How do people convince others to change their attitudes, beliefs, and behaviors? What communications do you receive that attempt to persuade you to change your attitudes, beliefs, and behaviors?
68.8K
Bone Cells and Tissue01:30

Bone Cells and Tissue

8.5K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.5K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

3.0K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
3.0K
Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

9.7K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
9.7K
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.9K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation.

Advanced healthcare materials·2026
Same author

Synergistic antibacterial effect of photocatalytic coatings activated by visible light and photodynamic therapy for rapid peri-implantitis treatment.

Bioactive materials·2026
Same author

A Humanized Bone Metastasis Model: <i>Ex Vivo</i> and <i>In Vivo</i> Applications.

Tissue engineering. Part C, Methods·2026
Same author

Inflammatory bone loss and signaling pathways in periodontitis: mechanistic insights and emerging therapeutic strategies.

Bone research·2026
Same author

Targeted Infection Control and Tissue Integration via pH-Sensitive Smart Coatings on Implant Surfaces.

ACS applied materials & interfaces·2025
Same author

Harnessing Advances in Bone Tissue Engineering for Design of Bone-on-Chip Systems.

Advanced healthcare materials·2025

Related Experiment Video

Updated: Feb 12, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.1K

Intraoperative Construct Preparation: A Practical Route for Cell-Based Bone Regeneration.

Yang Zhang1, Johanna F A Husch1, Jeroen J J P van den Beucken1

  • 1Department of Biomaterials, Radboudumc, Nijmegen, The Netherlands .

Tissue Engineering. Part B, Reviews
|April 11, 2018
PubMed
Summary

Intraoperative bone tissue engineering simplifies treatment for bone defects by preparing cell constructs during surgery. This avoids lengthy lab work and extra surgeries, making it more practical and cost-effective.

Keywords:
MSCsbone tissue engineeringintraoperativenew therapyregenerative medicine

More Related Videos

Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

11.5K
Intraoperative Ultrasound in Spinal Surgery
05:53

Intraoperative Ultrasound in Spinal Surgery

Published on: August 17, 2022

5.4K

Related Experiment Videos

Last Updated: Feb 12, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.1K
Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

11.5K
Intraoperative Ultrasound in Spinal Surgery
05:53

Intraoperative Ultrasound in Spinal Surgery

Published on: August 17, 2022

5.4K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Current stem cell bone tissue engineering requires extensive ex vivo cell expansion, which is impractical and costly.
  • This lengthy process involves significant laboratory manipulation and often an additional surgery for cell harvesting.

Purpose of the Study:

  • To introduce and discuss the concept of intraoperative bone tissue engineering.
  • To review cellular options, preparation methods, and existing studies for intraoperative constructs.
  • To identify challenges and future perspectives for this emerging approach.

Main Methods:

  • Discussion of intraoperative construct preparation strategies.
  • Review of preclinical and clinical data on intraoperatively prepared bone constructs.
  • Analysis of cellular sources suitable for same-day surgical preparation.

Main Results:

  • Intraoperative preparation offers a simplified, cost-effective alternative to traditional methods.
  • Several cellular options and preparation techniques are viable for same-day construct creation.
  • Existing studies show promise for intraoperative constructs in bone regeneration.

Conclusions:

  • Intraoperative bone tissue engineering presents a practical solution to current limitations.
  • Overcoming identified obstacles through technological innovation is key for clinical translation.
  • This approach holds significant potential for advancing bone defect and fracture treatments.