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Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
Published on: August 17, 2018
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Single Session Low Frequency Left Dorsolateral Prefrontal Transcranial Magnetic Stimulation Changes Neurometabolite
Nathaniel R Bridges1, Richard A McKinley2, Danielle Boeke2
1Infoscitex Inc., Dayton, OH, United States.
Frontiers in Human Neuroscience
|April 11, 2018
Summary
A single session of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) did not alter neurometabolites in healthy adults. However, it did change metabolite correlations and induced widespread brain activation, suggesting complex neuromodulatory effects.
Area of Science:
- Neuroscience
- Neuromodulation
- Brain Stimulation
Background:
- Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) of the dorsolateral prefrontal cortex (DLPFC) is a promising tool in research and treatment.
- While effects in psychiatric disorders are studied, understanding molecular changes and functional links in healthy individuals requires further investigation.
Purpose of the Study:
- To quantify neuromolecular changes after a single DLPFC LF-rTMS session in healthy participants.
- To correlate these molecular changes with functional and behavioral outcomes.
Main Methods:
- Eleven healthy participants underwent sham-controlled, neuronavigated 1 Hz rTMS targeting the left DLPFC during a working memory task.
- Changes in task performance, brain activation via fMRI, and neurometabolites via proton Magnetic Resonance Spectroscopy (MRS) were measured pre- and post-stimulation.
Main Results:
- A single LF-rTMS session did not significantly alter DLPFC neurometabolite levels or correlate with activation changes.
- Real rTMS altered neurometabolite correlations compared to sham, affecting baseline and inter-metabolite relationships.
- Real rTMS was linked to reduced reaction time improvements and increased activation in motor, somatosensory, and lateral occipital cortices.
Conclusions:
- A single session of LF-rTMS influences neurometabolite relationships and causes widespread brain activation in healthy humans.
- Investigating correlational relationships among metabolites may reveal underlying mechanisms of LF-rTMS.
Keywords:
dorsolateral prefrontal cortex (DLPFC)healthy subjectslow frequencymagnetic resonance spectroscopysternberg tasktranscranial magnetic stimulation (TMS)More Related Videos
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