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Ghrelin - Physiological Functions and Regulation.

Mona Mohamed Ibrahim Abdalla1

  • 1Senior Lecturer, Physiology Department, Faculty of Medicine, MAHSA University, Malaysia.

European Endocrinology
|April 11, 2018
PubMed
Summary
This summary is machine-generated.

Ghrelin, a stomach-secreted peptide, stimulates appetite and growth hormone release. This review details ghrelin's diverse physiological functions and factors influencing its circulating levels.

Keywords:
Ghrelinfood intakeghrelin receptorslipolysisobesityregulation

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolism

Background:

  • Ghrelin is an orexigenic peptide primarily secreted by the stomach.
  • It plays a crucial role in regulating appetite and growth hormone (GH) release.

Purpose of the Study:

  • To provide a comprehensive overview of ghrelin's physiological functions.
  • To discuss the factors influencing circulating ghrelin levels.

Main Methods:

  • Literature review of existing studies on ghrelin.
  • Synthesis of information on ghrelin's diverse roles and regulation.

Main Results:

  • Ghrelin regulates food intake, energy metabolism, cardiovascular function, bone formation, neurogenesis, and myogenesis.
  • Acylated ghrelin mediates most of these functions.
  • Ghrelin impacts gastric acid secretion, gastric motility, and pancreatic protein output.

Conclusions:

  • Ghrelin is a multifunctional peptide with significant physiological roles.
  • Understanding the balance of ghrelin secretion, degradation, and clearance is key to comprehending its circulating levels and effects.