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Severe Hypercalcaemia - Chronic Tophaceous Gout as the Responsible Cause?
René Rodríguez-Gutiérrez1,2, Maria Azucena Zapata-Rivera1, Karla Victoria Rodriguez-Velver1
1Endocrinology Division, Department of Internal Medicine, University Hospital 'Dr José E González', Unlversldad Autonoma de Nuevo León, Monterrey, México.
This case study highlights a rare instance of severe hypercalcemia in chronic tophaceous gout, linked to elevated parathyroid hormone-related protein (PTHrP). This finding offers new insights into hypercalcemia mechanisms in gout patients.
Area of Science:
- Nephrology
- Rheumatology
- Endocrinology
Background:
- Chronic tophaceous gout is rarely associated with severe hypercalcemia.
- Previous cases typically linked hypercalcemia to elevated calcitriol (1-25 dihydroxyvitamin D).
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