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Fluorescence-guided surgery and intervention - An AAPM emerging technology blue paper.
Brian W Pogue1, Timothy C Zhu2, Vasilis Ntziachristos3
1Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Fluorescence-guided surgery (FGS) uses fluorescent tracers to help surgeons detect and remove lesions. This emerging technology offers therapeutic benefits but requires addressing unique optical imaging challenges for safe and effective clinical use.
Area of Science:
- Medical Physics
- Surgical Technology
- Optical Imaging
Background:
- Fluorescence-guided surgery (FGS) is an evolving interventional approach utilizing fluorescent molecular tracers.
- Specialties use optical imaging to guide decisions on pathological lesion detection and excision/ablation.
- Commercialized applications exist, but optical imaging presents unique technical challenges.
Purpose of the Study:
- To outline key parameters, stakeholders, impacts, and outcomes of clinical FGS technology.
- To inform the medical physics field about FGS.
- To stimulate discussion on advancing FGS safely and effectively.
Main Methods:
- Publication of an AAPM Blue Paper by The Emerging Technology Working Group (TETAWG).
- Creation of an AAPM Task Group from the Therapy Physics Committee.
- Document outlines relevant issues, parameters, and applications of FGS.
Main Results:
- Identified key parameters, stakeholders, impacts, and outcomes of clinical FGS.
- Highlighted technical challenges unique to optical imaging in FGS.
- Emphasized the potential therapeutic impact of this imaging technology.
Conclusions:
- FGS is a low-risk imaging technology with high therapeutic potential.
- Consensus on guidelines and standards is needed for safe and effective advancement.
- Further discussion within the medical physics community is encouraged.
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