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Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening

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Published on: February 17, 2018

Occult dysraphism presenting with acro-osteolysis.

Hima Gopinath¹, Meghana Valeti¹, Kaliaperumal Karthikeyan¹

¹Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry University, Pondicherry, India.

Pediatric Dermatology

|April 11, 2018

Summary

Cutaneous stigmata, like skin and nerve issues, can signal hidden spinal problems. A child

Keywords:

acro-osteolysis foot ulcer occult spinal dysraphism

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Area of Science:

Neuroscience
Dermatology
Embryology

Background:

The skin and nervous system originate from the same embryonic tissues.
Spinal dysraphism encompasses a range of congenital conditions affecting spinal cord development.

Observation:

A 4-year-old child presented with acro-osteolysis and skin changes on the right foot.
These findings were indicative of an underlying, previously undiagnosed spinal dysraphism.

Findings:

Cutaneous manifestations can serve as early indicators of occult spinal dysraphism.
Delayed symptoms of spinal dysraphism may also manifest in the skin.

Implications:

Recognizing skin abnormalities is crucial for diagnosing spinal dysraphism in pediatric patients.
This case highlights the importance of considering neurological origins for seemingly isolated cutaneous and bone conditions.