Related Experiment Video

Updated: Feb 12, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K

ANP32E induces tumorigenesis of triple-negative breast cancer cells by upregulating E2F1

Zhenchong Xiong1, Liping Ye2, He Zhenyu3

  • 1Department of Breast Surgery, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Molecular Oncology
|April 11, 2018
PubMed

Insights

Acidic nuclear phosphoprotein 32 family member E (ANP32E) is highly expressed in triple-negative breast cancer (TNBC). High ANP32E levels indicate poor prognosis and promote TNBC cell proliferation by inducing cell cycle transition.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) is aggressive and lacks targeted therapies.
  • Effective prognostic markers and therapeutic targets are crucial for improving TNBC patient outcomes.

Purpose of the Study:

  • To investigate the role of acidic nuclear phosphoprotein 32 family member E (ANP32E) in TNBC.
  • To determine if ANP32E can serve as a prognostic marker and therapeutic target for TNBC.

Main Methods:

  • Compared ANP32E expression in TNBC versus other breast cancers.
  • Correlated ANP32E expression with patient survival and recurrence using Cox-regression models.
  • Assessed ANP32E's effect on TNBC cell proliferation in vitro and tumor formation in vivo.
  • Investigated ANP32E's mechanism involving E2F1, cyclin E1, and cyclin E2.

Main Results:

  • ANP32E is significantly overexpressed in TNBC.
  • High ANP32E expression correlates with worse overall survival and increased recurrence risk in TNBC patients.
  • ANP32E promotes TNBC proliferation by inducing G1/S cell cycle transition via transcriptional induction of E2F1.
  • ANP32E inhibition suppressed tumor formation in vivo.

Conclusions:

  • ANP32E is an independent prognostic factor for TNBC.
  • ANP32E promotes TNBC tumorigenesis by regulating the G1/S transition through E2F1.
  • ANP32E represents a potential therapeutic target and prognostic marker for TNBC.
Keywords:
TNBCANP32EE2F1cell cycletumorigenesis

More Related Videos

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.8K
Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System10:51

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

4.7K

Related Concept Videos

Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.0K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Scalar and Vector Triple Products01:06

Scalar and Vector Triple Products

Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.5K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.3K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
635