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Induction of Ocular Surface Inflammation and Collection of Involved Tissues
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Topically applied 1% voriconazole induces dysplastic changes on the ocular surface: animal study
Gul Arikan1, Ezgi Karatas1, Banu Lebe2
1a Department of Ophthalmology , Dokuz Eylul University School of Medicine , Izmir , Turkey.
Cutaneous and Ocular Toxicology
|April 11, 2018
Summary
Topical 1% voriconazole eye drops may increase the risk of ocular surface dysplasia in rabbits. Ophthalmologists should consider this potential side effect when prescribing voriconazole eye drops.
Area of Science:
- Ophthalmology
- Toxicology
- Histopathology
Background:
- Topical voriconazole is used to treat fungal eye infections.
- Potential ocular surface toxicity requires investigation.
Purpose of the Study:
- To assess the risk of ocular surface dysplasia from topical 1% voriconazole eye drops.
- To evaluate histopathological changes in rabbit eyes following voriconazole administration.
Main Methods:
- New Zealand rabbits received topical 1% voriconazole or saline (control) for 60 days.
- Ocular tissues (cornea, conjunctiva) were examined histopathologically.
- Dysplasia was evaluated using hematoxylin-eosin staining.
Main Results:
- Mild to moderate dysplasia was observed in the limbus, cornea, and conjunctiva of voriconazole-treated eyes.
- No severe dysplasia or carcinoma in situ was detected.
- Control eyes showed no signs of dysplasia.
Conclusions:
- Topical voriconazole may be associated with ocular surface dysplasia.
- Further awareness is needed regarding this potential risk in clinical practice.
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