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[Nephrotuberculosis and urolithiasis].

E V Kulchavenya1,2, D P Kholtobin1,2, E V Brizhatyuk1,2

  • 1Tuberculosis Research Institute of Minzdrav of Russia.

Urologiia (Moscow, Russia : 1999)
|April 11, 2018
PubMed
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Urolithiasis and renal tuberculosis co-occur in 4.6% of cases, worsening prognosis. Tuberculosis treatment may increase urinary stone risk, necessitating further prevention research.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Urology

Background:

  • Urolithiasis and nephrotuberculosis present similar radiographic patterns, complicating differential diagnosis.
  • Understanding their co-occurrence is crucial for managing renal tuberculosis.

Purpose of the Study:

  • To determine the incidence of co-occurring nephrotuberculosis and urolithiasis.
  • To assess the impact of urolithiasis on the clinical course and prognosis of renal tuberculosis.

Main Methods:

  • Retrospective analysis of 843 patients with renal tuberculosis and 245 with urolithiasis.
  • Evaluation of 1088 medical records for disease co-occurrence and clinical presentation.
  • Biochemical analysis of serum calcium and phosphorus in related conditions.
Keywords:
clinical presentationdiagnosisfeaturesnephrotuberculosisurogenital tuberculosisurolithiasis

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Main Results:

  • Concomitant urolithiasis occurred in 4.6% of renal tuberculosis patients.
  • Comorbidity significantly increased symptom severity and doubled the risk of tuberculosis recurrence.
  • Antituberculosis chemotherapy increased oxalate and uric acid excretion, potentially promoting stone formation.

Conclusions:

  • While uncommon, urolithiasis significantly complicates nephrotuberculosis, worsening its prognosis.
  • Antituberculosis polychemotherapy may elevate the risk of urinary stone formation.
  • Further research is needed to develop strategies for preventing urolithiasis in patients with urogenital tuberculosis.