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Related Concept Videos

Spinal Cord01:26

Spinal Cord

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The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
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The Spinal Cord01:54

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The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
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The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
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The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
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Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
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Related Experiment Video

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Author Spotlight: Long-Term Spinal Cord Slice Culture for Advancing Spinal Cord Regeneration Therapies
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Microstructural imaging in the spinal cord and validation strategies.

J Cohen-Adad1

  • 1NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada; Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada.

Neuroimage
|April 11, 2018
PubMed
Summary

This review explores in vivo histology with magnetic resonance imaging (MRI) for non-invasively mapping spinal cord microstructure. It details quantitative MRI techniques and histological validation for disease diagnosis and treatment monitoring.

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Area of Science:

  • Neuroimaging
  • Biomedical Engineering
  • Histology

Background:

  • In vivo histology using MRI offers non-invasive tissue microstructure characterization.
  • Applications include biomarker discovery, developmental studies, disease diagnosis, and treatment monitoring.
  • The spinal cord presents unique challenges for in vivo imaging.

Purpose of the Study:

  • To review quantitative MRI (qMRI) techniques for mapping spinal cord microstructure.
  • To discuss challenges and solutions in acquiring and processing spinal cord MRI data.
  • To outline protocols for histological validation of in vivo imaging findings.

Main Methods:

  • Review of existing MRI techniques for axon and myelin imaging.
  • Focus on quantitative MRI (qMRI) methods.
  • Discussion of data acquisition, processing, and histological validation strategies.

Main Results:

  • Established MRI techniques for imaging spinal cord microstructure.
  • Identified challenges in data acquisition and processing.
  • Proposed protocols for histological validation.

Conclusions:

  • In vivo histology via MRI is a promising tool for spinal cord research.
  • Quantitative MRI techniques are crucial for microstructure mapping.
  • Histological validation is essential for accurate interpretation of MRI data.